Current Advancement in the Oxadiazole-Based Scaffolds as Anticancer Agents.

Autor:	Kapoor, Garima, Bhutani, Rubina, Pathak, Dharam Pal, Chauhan, Garima, Kant, Ravi, Grover, Parul, Nagarajan, Kandasamy, Siddiqui, Shadab Ahmad
Předmět:	ANTINEOPLASTIC agent development GROWTH factors PHARMACEUTICAL chemistry DRUG development CANCER chemotherapy
Zdroj:	Polycyclic Aromatic Compounds; 2022, Vol. 42 Issue 7, p4183-4215, 33p
Abstrakt:	Heterocyclic nucleus is vital in medicinal chemistry and has allured significant attention in chemotherapeutic domain. Oxadiazole, a five-membered nitrogen–oxygen-containing heterocyclic core has remarkable anticancer activity. Mechanism associated in defeating tumor corresponds with inhibiting various enzymes and growth factors. Considering the importance of oxadiazole and its derivatives in this panic issue worldwide, this review has discussed research carried out from last 7 years and also their future outlook in drug development as antineoplastic agents. The objective of this review is to emphasize on anticancer activity of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives. The precised features and framework of each research topic is introduced for helping the readers in understanding the perspective of the context in better way. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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