| Abstrakt: |
Objective: To study the effect of local endometrial scratching on the outcomes of intrauterine insemination cycle. Design: Randomized controlled trial. Study setting: Department of Obstetrics & Gynecology, JN Medical College, Aligarh Muslim University, Aligarh. Materials and methods: A total of 77 patients were enrolled in the study. Patients undergoing controlled ovarian stimulation with intrauterine insemination were randomly allocated in two groups. In group A (n=31), endometrial scratching was carried out on D8/ D9 of same menstrual cycle in which intrauterine uterine insemination (IUI) was performed and in group B (control group; n=31), endometrial scratching was not performed. Primary outcome was measured by pregnancy rate, while secondary outcome was measured by endometrial indices. Results: Pregnancy rate was 16.2% in group A in which endometrial scratching was carried out in IUI cycle, whereas in group B, pregnancy rate was 9.6%. Although in group A, pregnancy rate was higher when compared with group B, the results were not statistically significant (P > 0.05). The mean endometrial thickness of women in group A was 9.329±0.934 which was significantly higher than endometrial thickness of group B, that is, 7.72±2.0. In group A, greater number of women (41.93%, n=13) had zone 3 endometrial flow than group B (19.35%, n=6). However, the difference was not statistically significant (P > 0.05). Conclusion: Endometrial scratching in follicular phase in the same cycle of stimulation with IUI gives better pregnancy rate in comparison with IUI without endometrial scratching. However, the results can be of proven clinical significance only if larger group of population is studied. [ABSTRACT FROM AUTHOR] |
