| Autor: |
Lukasevics, Lukass, Cizikovs, Aleksandrs, Grigorjeva, Liene |
| Předmět: |
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| Zdroj: |
Chemical Communications; 9/11/2022, Vol. 58 Issue 70, p9754-9757, 4p |
| Abstrakt: |
Herein we report the cobalt-catalyzed, picolinamide-directed C–H bond imination protocol of phenylalanine derivatives using isocyanides and a Co(dpm)2 catalyst. A wide range of functional groups were tolerated under the reaction conditions, yielding imines in high yields. The obtained imine products can easily be transformed to 1-aminoisoquinoline derivatives under reductive conditions, providing an attractive alternative to already existing methodologies. The control experiments indicated that C–H activation might occur via an electrophilic pathway. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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