| Autor: |
Lewis, Luján Lidianys María, Dörschmann, Philipp, Seeba, Charlotte, Thalenhorst, Tabea, Roider, Johann, Iloki Assanga, Simon Bernard, Ruiz, Juan Carlos Gálvez, Del Castillo Castro, Teresa, Rosas-Burgos, Ema Carina, Plascencia-Jatomea, Maribel, Ezquerra Brauer, Josafat Marina, Klettner, Alexa |
| Předmět: |
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| Zdroj: |
Antioxidants; Aug2022, Vol. 11 Issue 8, pN.PAG-N.PAG, 20p |
| Abstrakt: |
In this study, we investigated the physicochemical properties and the effect of ommochromes from cephalopod's skin on the retinal pigment epithelium in regard to oxidative stress, ferroptotic cell death, inflammation, and VEGF secretion. Keywords: ommochromes; cephalopods; ferroptosis; glycative stress; retinal pigment epithelium; uveal melanoma; vascular endothelial growth factor; interleukin EN ommochromes cephalopods ferroptosis glycative stress retinal pigment epithelium uveal melanoma vascular endothelial growth factor interleukin N.PAG N.PAG 20 08/29/22 20220801 NES 220801 1. In this study, we investigate the effect of ommochromes derived from cephalopods on oxidative stress, ferroptotic cell death, inflammation, and VEGF secretion in ocular cells, focusing on the retinal pigment epithelium. The isolation of the chromatophoric granules and the extraction of the pigments (ommochromes) were carried out by means processes of solubilization of the octopus's ommochromes in acidified methanol (1% I v i / I v i HCl) followed by successive steps of centrifugation and sonication. [Extracted from the article] |
| Databáze: |
Complementary Index |
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