| Autor: |
Rivas-Arancibia, Selva, Hernández-Orozco, Eduardo, Rodríguez-Martínez, Erika, Valdés-Fuentes, Marlen, Cornejo-Trejo, Vanessa, Pérez-Pacheco, Nelva, Dorado-Martínez, Claudia, Zequeida-Carmona, Diana, Espinosa-Caleti, Isaac |
| Předmět: |
|
| Zdroj: |
Antioxidants; Aug2022, Vol. 11 Issue 8, pN.PAG-N.PAG, 23p |
| Abstrakt: |
Chengxian Xu et al. showed that Gpx4-dependent neutralization protects Treg cells from lipid peroxides, ferroptotic cell death, and in turn maintains Treg cell activation and function to control antitumor immunity. In addition, tumor and immune cells in the tumor microenvironment are capable of generating cytokines that favor the increase in Treg cells such as TGF- , which is a necessary mediator for the differentiation and survival of Treg cells [[59]]. The inhibitory role of Treg cells depends on cell contact-dependent inhibition through CD80/CD86 on APC cells, mainly dendritic cells, by the CTLA-4 receptor expressed on Treg cells [[81]]. Classically, the functions of Treg cells have been described in CD4+ T cells, but other immune cells such as some CD8+ T cells, gamma delta T cells ( T), or cytotoxic (natural killer or NKT) cells also have the ability to modulate the response immune. Treg Cells and Infections Low responsiveness and reduced proliferation of virus-specific T cells during chronic viral infection are associated with Treg cell expansion. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
