The Microalgal Diatoxanthin Inflects the Cytokine Storm in SARS-CoV-2 Stimulated ACE2 Overexpressing Lung Cells.

Autor: Sansone, Clementina, Pistelli, Luigi, Del Mondo, Angelo, Calabrone, Luana, Fontana, Angelo, Noonan, Douglas M., Albini, Adriana, Brunet, Christophe
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Zdroj: Antioxidants; Aug2022, Vol. 11 Issue 8, pN.PAG-N.PAG, 16p
Abstrakt: Cytokine Release from A549-hACE2 Cells The release of 120 cytokines in the media from the A549-hACE2 cells was analyzed through an antibody array using RayBiotech SP ® sp C-Series Human Cytokine Array C1000 (cat. Anti-Inflammatory Response and Protein Expression The expression levels of tumor necrosis factor receptor 1 (TNFR1) and receptor-interacting-serine/threonine-protein kinase 2 (RIP2) proteins were investigated in A549-hACE2 cells, treated or not with the pro-inflammatory interleukin 1 (IL-1 ) [[41]] and with or without Dt addition. Dt-Modulated Gene Expression in A549-hACE2 Cells Over the selected 84 genes involved in antiviral innate immunity cell response (Table S1), the A549-hACE2 cells treated with Dt at 0.1 ng mL SP -1 sp significantly modulated 15 genes related to the inhibition of the inflammatory response by decreasing all trigger factors in antiviral innate immunity (Figure 4). [Extracted from the article]
Databáze: Complementary Index