| Autor: |
Colomeu, Talita Cristina, de Figueiredo, Daniella, de Matos da Silva, Priscila, Fernandes, Luís Gustavo Romani, Zollner, Ricardo de Lima |
| Předmět: |
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| Zdroj: |
Antioxidants; Aug2022, Vol. 11 Issue 8, pN.PAG-N.PAG, 17p |
| Abstrakt: |
Previous reports corroborating our findings have shown that treatment of mouse embryo fibroblast cells (M.E.F.) and mouse colon cancer cells (C-26) with the polyphenol quercetin causes necrotic death in cell cultures by a pro-oxidant effect due to generation of superoxide anion in the mitochondria [[65]]. Concerning I P. alata i and polyphenols' effect on R.O.S. generation in CD4 and CD8 lymphocytes, we observe differential behavior of the polyphenols when compared with I P. alata i extract. I P. alata i extract and polyphenols had a similar effect on CD8 SP + sp T cells, decreasing the cell viability and increasing late apoptosis/necrosis. IC SB 50 sb of I P. alata i extract and polyphenols, determined by lymphocyte proliferation analysis, can induce mitochondrial depolarization, thereby increasing oxidative stress by N.O.S., R.O.S. and mitochondrial superoxide, causing cell membrane lipid peroxidation and cell death in T lymphocytes. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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