Prevalence of Mycobacterium tuberculosis in Sputum and Reported Symptoms Among Clinic Attendees Compared With a Community Survey in Rural South Africa.

Autor:	Govender, Indira, Karat, Aaron S, Olivier, Stephen, Baisley, Kathy, Beckwith, Peter, Dayi, Njabulo, Dreyer, Jaco, Gareta, Dickman, Gunda, Resign, Kielmann, Karina, Koole, Olivier, Mhlongo, Ngcebo, Modise, Tshwaraganang, Moodley, Sashen, Mpofana, Xolile, Ndung'u, Thumbi, Pillay, Deenan, Siedner, Mark J, Smit, Theresa, Surujdeen, Ashmika
Předmět:	TUBERCULOSIS epidemiology TUBERCULOSIS diagnosis HIV infections CHEST X rays SPUTUM SELF-evaluation INTERVIEWING HEALTH status indicators ACQUISITION of data MOBILE hospitals MEDICAL screening PRIMARY health care HIGHLY active antiretroviral therapy MYCOBACTERIUM tuberculosis TUBERCULOSIS DISEASE prevalence MEDICAL records DESCRIPTIVE statistics STATISTICAL sampling MICROBIAL sensitivity tests RURAL population SYMPTOMS
Zdroj:	Clinical Infectious Diseases; 7/15/2022, Vol. 75 Issue 2, p314-322, 9p
Abstrakt:	Background Tuberculosis (TB) case finding efforts typically target symptomatic people attending health facilities. We compared the prevalence of Mycobacterium tuberculosis (Mtb) sputum culture-positivity among adult clinic attendees in rural South Africa with a concurrent, community-based estimate from the surrounding demographic surveillance area (DSA). Methods Clinic: Randomly selected adults (≥18 years) attending 2 primary healthcare clinics were interviewed and requested to give sputum for mycobacterial culture. Human immunodeficiency virus (HIV) and antiretroviral therapy (ART) status were based on self-report and record review. Community: All adult (≥15 years) DSA residents were invited to a mobile clinic for health screening, including serological HIV testing; those with ≥1 TB symptom (cough, weight loss, night sweats, fever) or abnormal chest radiograph were asked for sputum. Results Clinic: 2055 patients were enrolled (76.9% female; median age, 36 years); 1479 (72.0%) were classified HIV-positive (98.9% on ART) and 131 (6.4%) reported ≥1 TB symptom. Of 20/2055 (1.0% [95% CI,.6–1.5]) with Mtb culture-positive sputum, 14 (70%) reported no symptoms. Community: 10 320 residents were enrolled (68.3% female; median age, 38 years); 3105 (30.3%) tested HIV-positive (87.4% on ART) and 1091 (10.6%) reported ≥1 TB symptom. Of 58/10 320 (0.6% [95% CI,.4–.7]) with Mtb culture-positive sputum, 45 (77.6%) reported no symptoms. In both surveys, sputum culture positivity was associated with male sex and reporting >1 TB symptom. Conclusions In both clinic and community settings, most participants with Mtb culture-positive sputum were asymptomatic. TB screening based only on symptoms will miss many people with active disease in both settings. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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