| Autor: |
Heredia Gutiérrez, Juan Carlos, Contreras Palafox, Gabriel Alejandro, Jimenez, Sergio Moreno, Camacho, Alejandro Rodriguez-, Gutiérrez Aceves, Guillermo Axayacalt |
| Předmět: |
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| Zdroj: |
Journal of Radiosurgery & SBRT; 2022 Supplement, Vol. 8, p181-181, 1p |
| Abstrakt: |
Objective: To determine the prognostic value of tumor sphericity in the volumetric response of brain metastases treated with stereotactic radiosurgery from different primary tumors and regardless of the number of lesions Material and methods: Retrospective analysis of patients with brain metastases treated with stereotactic radiosurgery in the National Institute of Neurology and Neurosurgery “Manuel Velasco Suarez” located in Mexico City, without previous whole brain radiotherapy, irrespective of the primary tumor and the number of lesions. The diagnostic contrast-enhanced T1-weighted magnetic resonance and the image at the end of the follow up were used to delineate the metastases and then it was processed using the LIFEx software to determine the volume and sphericity. The metastases were divided using a sphericity cutoff value of 0.8. The RANO-BM volumetric adaptation was used to classify the response. A statistical analysis was performed to determine the prognostic value. Results: The analysis was performed in 35 patients with a total number of 177 brain metastases, median age of 54 years (Range 65), all the patients had a Karnofsky performance status ranging from 80-100%, the median follow up was 18.4 months (Range 55.2 months), the most common primary tumors were: lung (24.9%), kidney (24.9%), breast (19.2%) and thyroid (17.5%). The median tumor sphericity was 0.777 (Range 0.347). There was a statistically significant difference (p=0.001) between the primary tumors and the sphericity value with a greater percentage of lung cancer metastases in the group of sphericity ≥ 0.8, and kidney, breast, and thyroid metastases in the group of sphericity < 0.8. Also, there was a statistically significant difference (p=0.015) in the brain metastases that presented an increase of volume greater than 72% at the end of follow up in the group of sphericity < 0.8. There was no difference in the groups that presented complete response and partial response between the sphericity classification. Conclusions: The tumor sphericity represents an important radiomic parameter that has diagnostic and prognostic value, this study found differences that may help to distinguish metastases of different primary tumors and it was found that less spheric metastases tend to present tumor progression at the end of the follow up. This study has the limitations of its retrospective nature but helps to stablish the relevance of radiomics in the diagnostic and prognostic value of brain metastases for future studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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