| Autor: |
Kovalev, R. A., Fedorova, N. D., Pantina, R. A., Semenova, E. V., Filatov, M. V., Varfolomeeva, E. Yu. |
| Zdroj: |
Biophysics; Jun2022, Vol. 67 Issue 3, p427-434, 8p |
| Abstrakt: |
Stochastic gene expression can play an important role in the fate of both each specific cell and the cell population as a whole. In this work, we demonstrate significant variability of p53 expression, up to its complete absence, in human primary glioblastoma cells, which is not observed in cells of normal FLEH fibroblasts and transferable tumour cell lines, such as HeLa and HT1080. At the same time, the variability of p53 expression in cells depends on the density of seeding. We show that when the transcription is suppressed with actinomycin D or the p53 gene is knocked down by RNA interference, the restoration of its expression level in cells proceeds stochastically. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink