| Abstrakt: |
Diabetes is the tenth most common comorbidity in coronavirus disease, hence COVID-19 patients with this disease showed higher mortality rates and worse outcomes. Therefore, Management of diabetes during the pandemic became more critical, especially in ensuring patients consume functional foods containing diets, such as sweet potato, cassava, and taro, among the top ten abundant-traditional tubers in Indonesia. These foods are rich in protein, vitamin C, thiamine, riboflavin, niacin, and dietary fibre. Carbohydrate-rich foods, which constitute around 60% of the average diet should be considered. This study evaluated the potential of the three most consumed Indonesian tubers; sweet potato, cassava, and taro, as functional foods for managing diabetes during the pandemic. These foods were selected based on their chemical composition, antioxidant activity, and in silico molecular docking against COVID-19 and diabetes-related target proteins. The target proteins are ACE2 (angiotensinconverting enzyme 2), TMPRSS-2 (transmembrane serine protease 2), DPP IV (dipeptidyl peptidase IV), and a-glucosidase. The results showed that sweet potato has the highest phenolic compounds content and antioxidant activity, valued at 7.40 ± 0.20 mg/g GAE and 9.39 ± 0.3%, respectively. Moreover, molecular docking results indicated that sweet potato phenolic compounds, namely isorhamnetin, peonidin, and catechin against DPP IV, isorhamnetin, peonidin, and quercetin against ACE2, isorhamnetin and quercetin against a-glucosidase, and epicatechin against TMPRSS2 strongly interacted with the target proteins. In conclusion, cassava, taro, and sweet potato were the most potential functional foods for diabetes management during the pandemic. [ABSTRACT FROM AUTHOR] |
