Vaccinia-Interleukin 2 Recombinant Virus or Exogenous Interleukin 2 Does Not Alter the Magnitude or Immune Response Gene Defects of the Cytotoxic T-Cell Response to Vaccinia Virus in Vivo.

Autor:	Müllbacher, A., Ramshaw, I. A., Coupar, B. E. H.
Předmět:	INTERLEUKIN-2 IMMUNE response VACCINIA MAJOR histocompatibility complex IMMUNOREGULATION VIRUS diseases in cattle POXVIRUS diseases IMMUNOLOGY
Zdroj:	Scandinavian Journal of Immunology; Jan1989, Vol. 29 Issue 1, p1-6, 6p
Abstrakt:	We investigated the role of interleukin 2 (IL-2), a T cell-derived lymphokine, in the generation of in vivo cytotoxic T-cell responses to vaccinia virus. We made use of a recombinant vaccinia virus encoding and expressing the murine IL-2 gene and recombinant IL-2 to test the role of IL-2 in the expression of major histocompatibility complex (MHC) class I determined immune response (Ir) gene defects in the response to vaccinia virus. IL-2 expressed either by the vaccinia virus vector or exogenous IL-2 does not alter Ir gene defects nor does IL-2 under such conditions elevate the cytotoxic T-cell response In general. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text