| Autor: |
Doherty, P. C., Bennink, J. R. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; Oct1980, Vol. 12 Issue 4, p271-280, 10p |
| Abstrakt: |
This article discusses about an examination of major histocompatibility complex glycoprotein (MHC) restriction in the context of a minimal clonal abortion model for self tolerance. The fact that T-cell responses to non-self (virus) are always constrained by association with MHC has general implications for the theory of immunological tolerance. The tolerance problem may no longer be seen simply as a need to distinguish between two opposites, self and non-self. The central question now concerns the nature of the distinction between self and self plus other (self+x). The physiological mechanisms underlying MHC restriction and self tolerance must be considered concurrently. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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