One Third of Murine Splenic T Cells Are Cytotoxic Precursors Induced to Grow by Leucoagglutinin and TCGF.

Autor: Larsson, E.-L.
Předmět:
Zdroj: Scandinavian Journal of Immunology; May1982, Vol. 15 Issue 5, p515-519, 5p
Abstrakt: The frequency of leucoagglutinin (LA)-inducible, TCGF-reactive T cells has been determined using a sensitive limiting-dilution assay. The frequency of cells proliferating in TCGF-CM was 1 in 3, and the frequency of lectin-dependent cytotoxic T lymphocyte precursors (CTL-p) was 1 in 3-4. By analysing individual clonal cultures for proliferation and cytotoxic potential, a selective induction of CTL-p was detected, as all proliferating clones were found to mediate lectin-dependent cytotoxicity. [ABSTRACT FROM AUTHOR]
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