| Autor: |
Torabi bashkani, Elahesadat, Yasserian, Kiomars, Hosseini, Hamideh Mahmoodzadeh, Borghei, Majid, Sari, Amir Hossein |
| Zdroj: |
Brazilian Journal of Physics; Oct2022, Vol. 52 Issue 5, p1-6, 6p |
| Abstrakt: |
The interaction of atmospheric low-temperature plasma with living cells has been studied for its ability to induce colorectal cancer plasma therapy. To investigate the side effects of the plasma therapy, we analyzed the plasma interaction with both colorectal cancer cells (HT29) and non-cancer cells (HEK). The plasma plume properties have been studied using the Schillern method and optical emission spectroscopy (OES). The cell number has been controlled using the MTT method for cancer and non-cancer cells. The interaction of the plasma with cells has been studied by two different methods: direct and indirect (producing the plasma-activated medium). In addition, the comparison between optimum values for exposure time has been made. Furthermore, the amount of the hydrogen peroxide in the plasma-activated medium (one of the reasons for the cell death) has been measured for different physical conditions. Moreover, the aging time, which shows the time of retaining the plasma-activated medium potency against the colorectal cells, has been obtained. The results show that the direct interaction of the plasma with the growth medium leads to killing the colorectal cancer cells, but the rate of non-cancer cell death is more pronounced. However, by producing plasma-activated medium as an indirect method, the death rate of the colorectal cancer cells is higher than of the non-cancer cells and therefore, its side effects become negligible. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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