| Autor: |
Pilkington, G. R., Lee, G. T. H, O'Keefe, D., Plain, M., Wilson, F. C., Jose, D. G. |
| Zdroj: |
Australian Journal of Experimental Biology & Medical Science; Feb1980, Vol. 58 Issue 1, p27-39, 13p |
| Abstrakt: |
This article details a study classifying acute lymphocytic leukemia (ALL) in children, using rabbit antisera to leukemia cells and lymphoblastoid cell lines. The study used a report of the development, standardization and preliminary results of testing 6 heterologous antisera using a rapid simple complement-dependent cytotoxic assay to further sub-classify the major leukemia population in children with ALL Antisera used were raised to NALM-I, a Null-lymphoblastoid cell line expressing cALL antigen. Children studied were newly diagnosed cases of ALL referred to the Department of Clinical Hematology and Oncology, Royal Children's Hospital, Melbourne, between June 1978 and Mareh 1979, inclusive. Diagnosis of ALL was made clinically and by hematological assessment of blood and bone marrow. No appreciable cytotoxicity for normal blood mononuclear cells was observed with any antiserum except anti T-cell serum which produced 50-100% lysis, consistent with a normal blood T-lymphocyte population. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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