Copper‐Catalyzed Oxidative Cascade Inter‐Molecular Double Cyclization of 2‐Iodobenzamide Derivatives and Propargyl Dicarbonyl Compounds for Accessing 3‐Hydroxy‐3‐Furylisoindolinone Derivatives.

Autor:	Kavala, Veerababurao, Lin, Li‐Chun, Bhimrao Patil, Prakash, Fang, Chia‐Chi, Hong, Zih‐Yu, Liou, Yi‐Ru, Chen, Yu‐Nong, Weng, Yin‐Zhi, Sarathkumar, Sundaramoorthi, Sambasiva Rao, Naidu, Suresh, Sundaram, Jiang, Zongyan, Yao, Ching‐Fa
Předmět:	RING formation (Chemistry) AROMATIC compounds OXYGEN compounds
Zdroj:	Advanced Synthesis & Catalysis; 8/16/2022, Vol. 364 Issue 16, p2801-2814, 14p
Abstrakt:	A one‐pot strategy for the synthesis of 3‐hydroxy‐3‐furylisoindolinone derivatives is reported. The reaction proceeds via a copper‐catalyzed oxidative cascade inter‐molecular double cyclization of 2‐iodobenzamide derivatives and propargyl dicarbonyl compounds in the presence of oxygen. The strategy involves several reactions including cyclization/coupling/double C(sp3)−H functionalization in a cascade manner. A wide range of 2‐iodobenzamide substrates containing different substituents as well as various propargyldicarbonyl compounds and propargylsulfonyl aryl ketones can be used to access a variety of 3‐hydroxy‐3‐furylisoindolinone derivatives. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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