Inhibition of α-Amylase, α-Glucosidase, and Lipase, Intestinal Glucose Absorption, and Antidiabetic Properties by Extracts of Erodium guttatum.

Autor:	Benrahou, Kaoutar, Naceiri Mrabti, Hanae, Bouyahya, Abdelhakim, Daoudi, Nour Elhouda, Bnouham, Mohamed, Mezzour, Hicham, Mahmud, Shafi, Alshahrani, Mohammed Merae, Obaidullah, Ahmad J., Cherrah, Yahia, Faouzi, My El Abbes
Předmět:	GLUCOSE metabolism LIPASES BIOLOGICAL models IN vitro studies MEDICINAL plants IN vivo studies HYPERGLYCEMIA ANIMAL experimentation HYPOGLYCEMIC agents BLOOD sugar RATS TYPE 2 diabetes GLYCOSIDASES INTESTINAL absorption PLANT extracts MICE PHARMACODYNAMICS
Zdroj:	Evidence-based Complementary & Alternative Medicine (eCAM); 8/17/2022, p1-10, 10p, 5 Charts, 4 Graphs
Abstrakt:	Erodium guttatum is widely used in traditional medicine to treat various diseases, including diabetes. In this study, we evaluated in vitro inhibitory activity of extracts of E. guttatum on α-amylase, α-glucosidase, and lipase and then studied in vivo using different animal models. The results showed that the aqueous and alcoholic extracts of E. guttatum significantly inhibited digestive enzymes. The extracts of E. guttatum significantly reduced postprandial hyperglycemia after starch loading in normal rats. Additionally, extracts of E. guttatum significantly decrease the intestinal absorption of D-glucose. However, the methanolic extract of E. guttatum showed remarkable antidiabetic activity compared to the aqueous and ethanolic extracts of E. guttatum. In addition, the extracts significantly reduced blood sugar levels in albino mice and hematological and biochemical profiles. Therefore, the results of this study show that the extracts of E. guttatum have antidiabetic effects and could therefore be suggested in the management of type 2 diabetes. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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