| Autor: |
La-ongthong, Kannika, Sawekteeratana, Natthapat, Klaysuk, Jasarin, Soorukram, Darunee, Leowanawat, Pawaret, Reutrakul, Vichai, Krobthong, Sucheewin, Wongtrakoongate, Patompon, Kuhakarn, Chutima |
| Předmět: |
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| Zdroj: |
Synlett; Sep2022, Vol. 33 Issue 14, p1411-1418, 8p |
| Abstrakt: |
A facile and convenient reaction of o -alkynylisocyanobenzenes with various active-methylene compounds, including 1,3-diesters, 1,3-diketones, β-keto esters, and β-keto amides, under Brønsted basic conditions, has been developed. Diethyl malonate reacted smoothly with a collection of o -alkynylisocyanobenzenes to provide the corresponding 2-quinolin-2-yl malonates in excellent yields. Acetylacetone gave a mixture of quinolin-4-yl and quinolin-2-yl derivatives. Acetoacetate esters and acetoacetyl amide derivative initially gave 2-quinolin-2-yl adducts that underwent partial deacetylation under the reaction conditions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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