Antibody-Dependent Lymphocyte-Mediated Cytotoxicity in an Allogeneic Human System.

Autor: Dickmeiss, E., Nielsen, L. S.
Předmět:
Zdroj: Scandinavian Journal of Immunology; Apr1974, Vol. 3 Issue 2, p199-207, 9p
Abstrakt: The in vitro reactivity of human alloimmune sera against human lymphocytes in a complement-dependent system is compared with the reactivity in a system based on the principle of antibody-dependent lymphocyte-mediated cytotoxicity (ADLC). The sensitivity by which ADLC detects antibody reactivity is a 100- to a 1000- fold greater than the sensitivity of the complement-dependent system. With a given serum, ADLC discloses reactivity against many more different lymphocytes than the complement-dependent system. This substantially broader reactivity in ADLC is presumably caused by cross-reactions in the HL-A system. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index