Clinical Impact of Dual Time Point 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Fusion Imaging in Pancreatic Cancer.

Autor:	Einama, Takahiro, Yamagishi, Yoji, Takihata, Yasuhiro, Konno, Fukumi, Kobayashi, Kazuki, Yonamine, Naoto, Fujinuma, Ibuki, Tsunenari, Takazumi, Kouzu, Keita, Nakazawa, Akiko, Iwasaki, Toshimitsu, Shinto, Eiji, Ishida, Jiro, Ueno, Hideki, Kishi, Yoji
Předmět:	PANCREATIC tumors PREOPERATIVE care REFERENCE values PREDICTIVE tests TIME CANCER relapse TREATMENT effectiveness RISK assessment TUMOR classification RADIOPHARMACEUTICALS RADIATION doses SURVIVAL analysis (Biometry) DEOXY sugars COMPUTED tomography SENSITIVITY & specificity (Statistics) EMISSION-computed tomography PROPORTIONAL hazards models DISEASE risk factors EVALUATION
Zdroj:	Cancers; Aug2022, Vol. 14 Issue 15, p3688-3688, 14p
Abstrakt:	Simple Summary: In pancreatic cancer, recurrence rates after surgery remain high. The ability to identify patients at risk of early recurrence before surgery will contribute to the selection of treatment strategies. We examined the value of preoperative dual time point (DTP) 18F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (FDG PET/CT) as a predictor of early recurrence in or the outcomes of patients with pancreatic cancer. The results showed that DTP FDG PET/CT may effectively predict relapse in patients, and the combination of SUVmax1 and ΔSUVmax% identified early recurrent patient groups more precisely than SUVmax1 alone. We examined the value of preoperative dual time point (DTP) 18F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (FDG PET/CT) as a predictor of early recurrence or the outcomes in patients with pancreatic cancer. Standardized uptake values (SUVs) in DTP FDG PET/CT were performed as preoperative staging. SUVmax1 and SUVmax2 were obtained in 60 min and 120 min, respectively. ΔSUVmax% was defined as (SUVmax2 − SUVmax1)/SUVmax1 × 100. The optimal cut-off values for SUVmax parameters were selected based on tumor relapse within 1 year of surgery. Optimal cut-off values for SUVmax1 and ΔSUVmax% were 7.18 and 24.25, respectively. The combination of SUVmax1 and ΔSUVmax% showed higher specificity and sensitivity, and higher positive and negative predictive values for tumor relapse within 1 year than SUVmax1 alone. Relapse-free survival (RFS) was significantly worse in the subgroups of high SUVmax1 and high ΔSUVmax% (median 7.0 months) than in the other subgroups (p < 0.0001). The multivariate Cox analysis of RFS identified high SUVmax1 and high ΔSUVmax% as independent prognostic factors (p = 0.0060). DTP FDG PET/CT may effectively predict relapse in patients with pancreatic cancer. The combination of SUVmax1 and ΔSUVmax% identified early recurrent patient groups more precisely than SUVmax1 alone. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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