| Autor: |
Williamson, Esther, Boniface, Graham, Marian, Ioana R, Dutton, Susan J, Garrett, Angela, Morris, Alana, Hansen, Zara, Ward, Lesley, Nicolson, Philippa J A, Rogers, David, Barker, Karen L, Fairbank, Jeremy C, Fitch, Judith, French, David P, Comer, Christine, Mallen, Christian D, Lamb, Sarah E, Group, BOOST Research, BOOST Research Group |
| Předmět: |
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| Zdroj: |
Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Aug2022, Vol. 77 Issue 8, p1654-1664, 11p |
| Abstrakt: |
Background: Neurogenic claudication (NC) is a debilitating spinal condition affecting older adults' mobility and quality of life.Methods: A randomized controlled trial of 438 participants evaluated the effectiveness of a physical and psychological group intervention (BOOST program) compared to physiotherapy assessment and tailored advice (best practice advice [BPA]) for older adults with NC. Participants were identified from spinal clinics (community and secondary care) and general practice records and randomized 2:1 to the BOOST program or BPA. The primary outcome was the Oswestry Disability Index (ODI) at 12 months. Data were also collected at 6 months. Other outcomes included ODI walking item, 6-minute walk test (6MWT), and falls. The primary analysis was intention-to-treat.Results: The average age of participants was 74.9 years (standard deviation [SD] 6.0) and 57% (246/435) were female. There was no significant difference in ODI scores between treatment groups at 12 months (adjusted mean difference [MD]: -1.4 [95% confidence intervals (CI) -4.03, 1.17]), but, at 6 months, ODI scores favored the BOOST program (adjusted MD: -3.7 [95% CI -6.27, -1.06]). At 12 months, the BOOST program resulted in greater improvements in walking capacity (6MWT MD: 21.7m [95% CI 5.96, 37.38]) and ODI walking item (MD: -0.2 [95% CI -0.45, -0.01]) and reduced falls risk (odds ratio: 0.6 [95% CI 0.40, 0.98]) compared to BPA. No serious adverse events were related to either treatment.Conclusions: The BOOST program substantially improved mobility for older adults with NC. Future iterations of the program will consider ways to improve long-term pain-related disability. Clinical Trials Registration Number: ISRCTN12698674. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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