Design and Preparation of β‐Lactam Derivatives Bearing Phenanthrenimidazole as Cytotoxic Agents.

Autor:	Alborz, Maryam, Pournejati, Roya, Ameri Rad, Javad, Jarrahpour, Aliasghar, Reza Karbalaei‐Heidari, Hamid, Michel Brunel, Jean, Turos, Edward
Předmět:	LACTAMS ANTI-inflammatory agents IMIDAZOLES ELEMENTAL analysis CELL lines ANTIBACTERIAL agents
Zdroj:	ChemistrySelect; 8/5/2022, Vol. 7 Issue 29, p1-12, 12p
Abstrakt:	In the present work, a novel series of monocyclic 1H‐phenanthro[9,10‐d]imidazole β‐lactam hybrids has been synthesized in yields varying from 70–95 % by a stereoselective [2+2]‐cyclocondensation (Staudinger reaction). The newly‐synthesized compounds and their imine intermediates were characterized by IR, 1H NMR, 13C NMR and elemental analyses. The 1H‐phenanthro[9,10‐d]imidazole β‐lactam hybrids showed moderate cytotoxicity towards two mammalian cancerous cell lines, MCF‐7 and A549, and to a lesser extent on immortalized normal fibroblast SV‐80 cells. In addition, hemolytic activity of the Phenanthren‐imidazole β‐lactam conjugates showed their potential as a medicine. None of the compounds displayed antibacterial or anti‐inflammatory activity. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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