| Autor: |
Feng, Shuxiao, Qi, Kaiyan, Ma, Junying, Guo, Yafei, Gao, Jiayu, Liu, Pu, Wang, Junling, Gu, Guangna, Dong, Le, Wang, Jinhua, Li, Wan, Yang, Yihui, Du, Guanhua, Qu, Lingbo, Zhang, Shouren |
| Zdroj: |
Chemical Papers; Sep2022, Vol. 76 Issue 9, p5471-5485, 15p |
| Abstrakt: |
As a new kind of unsymmetrical alkyl-aryl-selenides, a series of novel β-carbonyl-selenides derivatives were synthesized with high regioselectivity and substrates tolerance. Total six series and forty-four compounds were generated. The in vitro antiproliferative activities were evaluated on U251-MG, U87-MG, MDA-MB-231, HCT116 and SW620 cells lines. Structure and antiproliferative relationship were discussed. Among them, (±)-N, N′-(1,2-phenylene)-bis-(2-((3-oxobutan-2-yl)selanyl) benzamide) (5t) has significant antiproliferative activity and potential value as anticancer agent with IC50 values < 2.63 µM, while the IC50 values of Ebselen > 86.36 µM in test tumor cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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