| Autor: |
Hellström, U., Sylvan, S. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; May1986, Vol. 23 Issue 5, p545-553, 9p |
| Abstrakt: |
The circulatory pool of B cells, from donors immune to hepatitis B (HB) through natural infection, contained sensitized B cells with the capacity to secrete antibodies with specificity for human serum albumin (HSA) when stimulated with purified hepatitis B surface antigen (HBsAg) in vitro. The immunoglobulin secretion was dependent upon and regulated by T cells and specifically induced, since it was not obtained in cell cultures from HB-susceptible donors. Culture supernatants with anti-HSA reactivity also contained specific antibodies in HBsAg (anti-HBs), indicating that the outer coat of HBV normally provokes an immune response to both the viral antigen and a 'self component. Perturbation in the regulation of the immune response triggered by HSA in association with HBV/HBsAg particles may involve a putative risk for development of chronic HBsAg carriership. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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