Efficacy of Influenza Haemagglutinin and Nucleoprotein as Protective Antigens against Influenza Virus Infection in Mice.

Autor:	Andrew, M. E., Coupar, B. E. H.
Předmět:	RESPIRATORY infections INFLUENZA viruses VIRUS diseases in cattle VIRUSES T cells LEUCOCYTES
Zdroj:	Scandinavian Journal of Immunology; Jul1988, Vol. 28 Issue 1, p81-85, 5p
Abstrakt:	Influenza nucleoprotein (NP)-specific cytotoxic T lymphocytes (CTL) stimulated by immunization of mice with VV-PR8-NP6, a recombinant vaccinia virus expressing A/PR/8/34 NP, did not protect mice against challenge with A/PR/8/34 4 days later. Neither were secondary NP-specific CTL stimulated by reimmunization able to protect mice. These results contrast with the ability of transferred, in vitro-cultured and stimulated, NP-specific CTL to protect recipient mice from challenge with A/PR/8/34. Immunization of mice with a recombinant vaccinia virus expressing A/PR/8/34 HA protected mice challenged 4 days later, either via the small amount of antibody already present, or via HA-specific CTL that would have to be more efficient than NP-specific CTL in either trafficking to the infected lung or in effector function. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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