| Autor: |
Blomhoff, H. Kill, Davies, C., Ruud, E., Funderud, S., Godal, T. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; Dec1985, Vol. 22 Issue 6, p611-617, 7p |
| Abstrakt: |
The effect of γ interferon (IFN-γ) on proliferation and antigenic characteristics of cell lines belonging to the B-cell progenitor compartment was studied. We observed a selective effect of recombinant IFN-γ but not IFN-α on proliferation of the B-precursor cell lines Reh and KM3. On day 4, after addition of 400 μ/ml IFN-γ the [³H]thymidine uptake in these cells was reduced to 60% and 45% respectively, while no effect of IFN-γ was evident on the proliferation of the more mature B-cell lines Raji, Ramos, B85, and Daudi. On the other hand, both Reh and Ramos showed induction of major histocompatibility complex (MHC) class I antigen expression in response to 400 μ/ml IFN-γ. In contrast to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), IFN-γ did not induce increased MHC class II antigen expression on Reh cells. Taken together, our results indicate that IFN-γ fulfils distinct functions at different levels in the development of B cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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