Variation in cardiovascular disease risk factors among older adults in the Hunter Community Study cohort: A comparison of diet quality versus polygenic risk score.

Autor:	Reay, William R., Haslam, Rebecca, Cairns, Murray J., Moschonis, George, Clarke, Erin, Attia, John, Collins, Clare Elizabeth
Předmět:	CARDIOVASCULAR diseases risk factors HDL cholesterol TRIGLYCERIDES BLOOD plasma CARDIOVASCULAR diseases LDL cholesterol REGRESSION analysis NUTRITIONAL requirements DIET DESCRIPTIVE statistics QUESTIONNAIRES STATISTICAL models ODDS ratio DATA analysis software SECONDARY analysis LIPIDS PHENOTYPES OLD age
Zdroj:	Journal of Human Nutrition & Dietetics; Aug2022, Vol. 35 Issue 4, p675-688, 14p
Abstrakt:	Background: The interplay between cardiovascular disease (CVD) genetic risk indexed by a polygenic risk score (PRS) and diet quality still requires further investigation amongst older adults or those with established or treated CVD. The present study aimed to evaluate the relative contribution of diet quality, measured using the Australian Recommended Food Score (ARFS) and PRS, with respect to explaining variation in plasma lipids CVD outcomes in the Hunter Cohort. Methods: The study comprised a secondary analysis of cross‐sectional data from the Hunter Cohort study. Single‐nucleotide polymorphisms from previously derived polygenic scores (PGSs) for three lipid classes were obtained: low‐density lipoprotein, high‐density lipoprotein and triglycerides, as well as PRS for coronary artery disease (CAD) from the PGS catalogue. Regression modelling and odds ratios were used to determine associations between PRS, ARFS and CVD risk. Results: In total, 1703 participants were included: mean ± SD age 66 ± 7.4 years, 51% female, mean ± SD total ARFS 28.1 ± 8 (out of 74). Total diet quality and vegetable subscale were not significantly associated with measured lipids. By contrast, PGS for each lipid demonstrated a markedly strong, statistically significant correlation with its respective measured lipid. There was a significant association between CAD PRS and 5/6 CVD phenotypes (all except atrial fibrillation), with the largest effect size shown with coronary bypass. Adding dietary intake as a covariate did not change this relationship. Conclusions: Lipid PGS explained more variance in measured lipids than diet quality. However, the poor diet quality observed in the current cohort may have limited the ability to observe any beneficial effects. Future research should investigate whether the diet quality of older adults can be improved and also the effect of these improvements on changes in polygenic risk. Key points: The Australian Recommended Food Score (ARFS) had little association with lipid and cardiovascular disease (CVD) endpoints.Lipid polygenic score (PGS) explained more variance in measured lipids than diet quality.The lipid PGS was associated with all three lipid parameters and some CVD endpoints, especially high cholesterol.Coronary artery disease polygenic risk score was associated with CVD endpoints angina, coronary bypass, heart attack, high cholesterol and hypertension and some lipid parameters (high‐density lipoprotein cholesterol). [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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