| Abstrakt: |
A series of newer derivatives 10a–n containing a 2,4-thiazolidinedione and 2-aryl-4-thiazolidinone moieties of pharmacological significance have been synthesized. The compounds were screened for their in vitro antimicrobial activity against three Gram-positive bacteria Staphylococcus aureus, Bacillus cereus, and Micrococcus luteus and three Gram-negative bacteria Pseudomonas fluorescens, Escherichia coli, and Flavobacterium devorans. Among them,10c, 10d, 10i, 10j, 10k, 10l, and 10n displayed equipotent antibacterial activity against the tested strains. All synthesized compounds were also tested for their cytotoxic activity against HeLa and MCF-7 cell lines. This study shows that all compounds were non-cytotoxicin nature, and confirmed their antimicrobial specificity apart from any general cytotoxicity. All these synthesized compounds were characterized by 1H NMR, 13C NMR, and HRMS spectral techniques. [ABSTRACT FROM AUTHOR] |
