| Autor: |
Stolzenburg, T., Binz, H., Fontana, A., Felder, M., Wagenhaeuser, F.-J. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; Jan1988, Vol. 27 Issue 1, p73-81, 9p |
| Abstrakt: |
Peripheral blood lymphocytes from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS). Reiter's disease, osteoarthritis. and from healthy volunteers were investigated for interferon-γ (IFN-γ) production after mitogen activation. Phytohaemagglutinin stimulation revealed an impaired IFN-γ production in RA, SLE, and PSS but normal levels in Reiter's disease and osteoarthritis. In RA this deficiency was also seen after pokeweed mitogen. OKT3, and concanavalin A activation. No major differences were found in interleukin 2 (IL-2) production and cell proliferation. The IL-2 receptor expression was reduced on stimulated RA lymphocytes. The deficient IFN-γ production was compensated in RA by co-stimulation of PHA or OKT3 with phorbol myristic acetate (PMA). In addition, the combination of the calcium ionophore A 25187 and PMA induced a strong IFN-γ secretion in all patient groups and in the controls [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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