| Autor: |
Benesová, Michaela, Krivošík, Marek, Kosírová, Stanislava, Foltánová, Tatiana |
| Předmět: |
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| Zdroj: |
European Pharmaceutical Journal; 2022 Supplement, Vol. 69, p32-32, 1p |
| Abstrakt: |
Every year stroke affects 15 million people worldwide. It is fatal for 5 million of them and disabling for another 5 million. Anticoagulant treatment is a well-known stroke prevention measure. The aim of this work was to compare the results of the success in recanalization treatment (NIHSS) in patients with and without antithrombotic treatment in the anterior condition and to evaluate any change in pharmacotherapy after recanalization treatment in patients with antithrombotic treatment in predisease. We analysed data from 100 patients (59% men, 41% women) with an average age of 66.4 (SD = 1.4, range = 32-91) with ischemic stroke. All patients underwent intravenous thrombolysis in the acute care setting (M = 2.8 hr, maximum = 4.5 hr) and 10 of them also underwent mechanical thrombectomy. The door to needle time was 38.5 min, which fits the criterion of the AHA/ASA (less than 1 hr). The results of the average values of NIHSS with or without antithrombotic therapy in anamnesis were not significantly different. However, during hospitalisation, the values decreased significantly. The change in pharmacotherapy after the intervention in patients treated with antithrombotic therapy shows a significant difference between acetylsalicylic acid and clopidogrel. Whereas 53.7% of patients used acetylsalicylic acid on admission, at discharge it was only 25.0%. Clopidogrel was used in 36.6% of patients on admission, and we identified an increase in clopidogrel use to 55.6% at discharge. The use of statins also increased significantly, as up to 91.0% of patients left the hospital with statins at discharge. In terms of anticoagulant therapy, we identified an increase of apixaban use to 14.6% at discharge, which caused 15 patients to be diagnosed with nonvalvular fibrillation of atriums during hospitalisation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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