Current insight into the regulation of PD-L1 in cancer.

Autor:	Liu, Zhuandi, Yu, Xibao, Xu, Ling, Li, Yangqiu, Zeng, Chengwu
Předmět:	PROGRAMMED death-ligand 1 IMMUNE checkpoint proteins CELL-mediated cytotoxicity PROGRAMMED cell death 1 receptors CANCER cells
Zdroj:	Experimental Hematology & Oncology; 7/30/2022, Vol. 11 Issue 1, p1-16, 16p
Abstrakt:	The molecular mechanisms underlying cancer immune escape are a core topic in cancer immunology research. Cancer cells can escape T cell-mediated cellular cytotoxicity by exploiting the inhibitory programmed cell-death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1, CD274) immune checkpoint. Studying the PD-L1 regulatory pattern of tumor cells will help elucidate the molecular mechanisms of tumor immune evasion and improve cancer treatment. Recent studies have found that tumor cells regulate PD-L1 at the transcriptional, post-transcriptional, and post-translational levels and influence the anti-tumor immune response by regulating PD-L1. In this review, we focus on the regulation of PD-L1 in cancer cells and summarize the underlying mechanisms. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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