Pattern of recurrence and survival after D2 right colectomy for cancer: is there place for a routine more extended lymphadenectomy?

Autor: Palmeri, Matteo, Peri, Andrea, Pucci, Valentina, Furbetta, Niccolò, Gallo, Virginia, Di Franco, Gregorio, Pagani, Anna, Dauccia, Chiara, Farè, Camilla, Gianardi, Desirée, Guadagni, Simone, Bianchini, Matteo, Comandatore, Annalisa, Masi, Gianluca, Cremolini, Chiara, Borelli, Beatrice, Pollina, Luca Emanuele, Di Candio, Giulio, Pietrabissa, Andrea, Morelli, Luca
Zdroj: Updates in Surgery; Aug2022, Vol. 74 Issue 4, p1327-1335, 9p
Abstrakt: Background: Conventional Right Colectomy with D2 lymphadenectomy (RC-D2) currently represent the most common surgical treatment of right-sided colon cancer (RCC). However, whether it should be still considered a standard of care, or replaced by a routine more extended D3 lymphadenectomy remains unclear. In the present study, we aim to critically review the patterns of relapse and the survival outcomes obtained from our 11-year experience of RC-D2. Methods: Clinical data of 489 patients who underwent RC-D2 for RCC at two centres, from January 2009 to January 2020, were retrospectively reviewed. Patients with synchronous distant metastases and/or widespread nodal involvement at diagnosis were excluded. Post-operative clinical–pathological characteristics and survival outcomes were evaluated including the pattern of disease relapse. Results: We enrolled a total of 400 patients with information follow-up. Postoperative morbidity was 14%. The median follow-up was 62 months. Cancer recurrence was observed in 55 patients (13.8%). Among them, 40 patients (72.7%) developed systemic metastases, and lymph-node involvement was found in 7 cases (12.8%). None developed isolated central lymph-node metastasis (CLM), in the D3 site. The estimated 3- and 5-year relapse-free survival were 86.1% and 84.4%, respectively. The estimated 3- and 5-year cancer-specific OS were 94.5% and 92.2%, respectively. Conclusions: The absence of isolated CLM, as well as the cancer-specific OS reported in our series, support the routine use of RC-D2 for RCC. However, D3 lymphadenectomy may be recommended in selected patients, such as those with pre-operatively known CLM, or with lymph-node metastases close to the origin of the ileocolic vessels. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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