| Autor: |
Alalim, Hussain Nihad Izaddin, Eken, Başak Funda, Ulucan, Korkut, Özdemir, Fulya |
| Předmět: |
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| Zdroj: |
Turkish Journal of Orthodontics; Jun2022, Vol. 35 Issue 2, p127-132, 6p |
| Abstrakt: |
Objective: A functional polymorphism on the 16th exon of the alpha-actinin-3 gene has an effect on the protein structure and cellular signaling and therefore on muscle contraction. In this study, we aimed to analyze the alpha-actinin-3 rs1815739 polymorphism in 3-dimensional malocclusions and different craniofacial skeletal patterns. Methods: Forty-nine volunteering subjects enrolled for the study. Genotyping of alpha-actinin-3 rs1815739 polymorphism was performed using real-time polymerase chain reaction. Pre-orthodontic cephalometric radiographs were traced using NemoTech cephalometric tracing software. IBM SPSS Statistics for Windows was utilized to carry out statistical analysis. P < .05 was considered to be statistically significant. Results: The respective numbers and the percentages of alpha-actinin-3 rs1815739 polymorphisms for RR, RX, and XX genotypes were 39 (79.6%), 4 (8.2%), and 6 (12.2%), respectively. Twenty-one patients had low angle vertical patterns and 17 patients had Class I and the same number of the patients had Class III facial patterns. But none of these had statistically significant difference in terms of alpha-actinin-3 rs1815739 polymorphism and in vertical or sagittal facial patterns, and mandibular incisor inclination. When we examined the maxillary anteroposterior position, we found a significant difference between rs1815739 polymorphisms (P < .05). Also, we detected a significant difference between rs1815739 polymorphism and maxillary incisor inclination (P < .05). Conclusion: Maxillary incisor inclination and maxillary anteroposterior position are associated with alpha-actinin-3 rs1815739 polymorphism in a Turkish cohort. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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