| Autor: |
Silva, Cecília Maria F., Mota, Higor F., de O. Cabra, Felipe, Farias, Yuri V., Dimas, Stefany M., de Santana, Giorgio S., de Gusmão, Letícia N. M., Nogueira, Bárbara A., Ramos, Juliana N., de Souza, Monica Cristina, de S. Leão, Robson, de Oliveira, Marcus Vinícius G., Santos, Louisy S. dos, Mattos-Guaraldi, Ana Luíza, de Souza, Cassius |
| Předmět: |
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| Zdroj: |
Brazilian Journal of Health & Biomedical Sciences; Jul-Dec2021, Vol. 20 Issue 2, p114-128, 15p |
| Abstrakt: |
Nowadays, Corynebacterium striatum has been reported as etiologic agent of mild to severe hospital-acquired infections, including patients undergoing endotracheal intubation with fatal outcome. A continuous survey of infections due multidrug- resistant (MDR) C. striatum in South American countries remains necessary. This retrospective and prospective study aimed to analyze clinical-microbiological features of C. striatum clinical isolates from patients attended at a Brazilian tertiary care hospital, during a nine-year period. C. striatum strains (n=130) were isolated from infected patients attended at twenty nosocomial wards, mainly of tracheal aspirate (n=53) and blood and/or intravenous catheter (n=21/n=13). Notably, original cases of nosocomial infections due to C. striatum were verified in children making use of invasive devices, including one fatal neonatal case, in addition to a fatal respiratory infection in patient with cystic fibrosis, as well as urinary tract infections of kidney transplant recipients. Most of C. striatum strains expressed MDR profiles (88.46%). Emergence of vancomycin (1.90%) and linezolid (7.41%) resistance was verified among MDR and non-MDR-strains. In conclusion, endemic condition with wide dissemination among hospital wards of varied types of infections due to MDR and non-MDR C. striatum strains expressing heterogenic virulence potential and genetic features may occur in hospital units. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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