| Autor: |
Klimovica, Kristine, Heidlas, Julius X., Romero, Irvin, Le, Thanh V., Daugulis, Olafs |
| Předmět: |
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| Zdroj: |
Angewandte Chemie International Edition; Aug2022, Vol. 61 Issue 31, p1-6, 6p |
| Abstrakt: |
We report here "sandwich" diimine‐copper(I) catalysts for C(sp3)−H bond functionalization. Reactions of alkanes and ethers with trimethylsilyldiazomethane, ethyl diazoacetate, and trifluoromethyl‐diazomethane have been demonstrated. We also report C(sp3)−H bond methylation, benzylation, and diphenylmethylation by diazomethane, aryldiazomethanes, and diphenyldiazomethane. These reactions are rare examples of base‐metal catalyzed, intermolecular C(sp3)−H functionalizations by employing unactivated diazo compounds. Electrophilicity and unique steric environment of "sandwich"‐copper catalysts are likely reasons for their catalytic efficiency. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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