Effect modification in a clinical trial should be assessed through interaction terms, not prognostic modelling.

Autor: Roepke, Roberta M. L., Mendes, Pedro V., Cardozo Junior, Luis C. M., Park, Marcelo, Besen, Bruno A. M. P.
Zdroj: Intensive Care Medicine; Aug2022, Vol. 48 Issue 8, p1122-1124, 3p, 1 Chart
Abstrakt: We read with interest the secondary analysis of the NUTRIREA-2 trial published in Intensive Care Medicine [[1]]. These results are compelling: among patients < 24 h under mechanical ventilation and using vasopressors or inotropes, there is a higher risk of AMI and other gastrointestinal adverse events. Nutrition in critical illness should be titrated to patient's clinical condition in the early phase of critical illness. [Extracted from the article]
Databáze: Complementary Index
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