| Autor: |
Deng, Yong-Qiang, Wang, Zhen-Xing, Liu, Xin, Wang, Yi-Yi, Chen, Qi, Li, Zhao-Long, Zheng, Bai-Song, Ye, Qing, Gong, Jiang-Shan, Zhu, Guo-Qiang, Cao, Tian-Shu, Situ, Wei-Yi, Qin, Cheng-Feng, Xie, Hui, Zhang, Wen-Yan |
| Zdroj: |
Journal of Materials Chemistry B; 7/28/2022, Vol. 10 Issue 28, p5454-5464, 11p |
| Abstrakt: |
The SARS-CoV-2 pandemic has become a severe global public health event, and the development of protective and therapeutic strategies is urgently needed. Downregulation of angiotensin converting enzyme 2 (ACE2; one of the important SARS-CoV-2 entry receptors) and aberrant inflammatory responses (cytokine storm) are the main targets to inhibit and control COVID-19 invasion. Silver nanomaterials have well-known pharmaceutical properties, including antiviral, antibacterial, and anticancer properties. Here, based on a self-established metal evaporation-condensation-size graded collection system, smaller silver particles reaching the Ångstrom scale (AgÅPs) were fabricated and coated with fructose to obtain a stabilized AgÅP solution (F-AgÅPs). F-AgÅPs potently inactivated SARS-CoV-2 and prevented viral infection. Considering the application of anti-SARS-CoV-2, a sterilized F-AgÅP solution was produced via spray formulation. In our model, the F-AgÅP spray downregulated ACE2 expression and attenuated proinflammatory factors. Moreover, F-AgÅPs were found to be rapidly eliminated to avoid respiratory and systemic toxicity in this study as well as our previous studies. This work presents a safe and potent anti-SARS-CoV-2 agent using an F-AgÅP spray. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
