| Abstrakt: |
This report presents a case of canine mucocutaneous Bowen's disease developing underneath a cutaneous horn in the anal region. A 7-month-old female German shepherd was diagnosed with two fused cutaneous horns in the anal region. Macroscopically, two conical, exophytic horn-like tissues were seen, fused, and sharing an irregular basal soft tissue, possessing parallel longitudinal grooves. Histopathologically, it was composed of a deep verrucous hyperkeratotic zone of squamous cell carcinoma in situ (Bowen's disease) and an overlying cutaneous horn. Marked orthokeratosis, hypergranulosis, cellular basophilia and vacuolation, intranuclear inclusion bodies, moderate to severe pleomorphism, and mitotic activity were noted. While polymerase chain reaction failed to detect canine papillomavirus L1 gene, the presence of papillomavirus was confirmed by p16 immunostaining. Strong CK5/6, weak p53, and Ki-67 immunostaining, and negative expression of vimentin supported the diagnosis of Bowen's disease, a non-invasive squamous lesion with low malignancy potential. [ABSTRACT FROM AUTHOR] |
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