| Autor: |
deSmet, Kris, Reekmans, Rieka, Contreras, Roland |
| Předmět: |
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| Zdroj: |
Biotechnology Letters; Dec2004, Vol. 26 Issue 23, p1781-1785, 5p |
| Abstrakt: |
The succeptibility ofSaccharomyces cerevisiaeto the anti-microbial peptide, histatin 5, was tested after pre-growth in fermentable and non-fermentable carbon sources and in the absence or presence of the uncoupler of oxidative phosphorylation, carbonyl cyanidem-chlorophenylhydrazone (CCCP).S. cerevisiaewas more resistant to histatin 5 when grown on a fermentable carbon source compared to growth on a non-fermentable carbon source, indicating an important role for oxidative phosphorylation in histatin 5-induced cell death. Oxidative phosphorylation is a pre-requisite for histatin 5-induced cell death inCandida albicansbut this is not the case inS. cerevisiae. Incubation of CCCP-treatedS. cerevisiaecells with histatin 5 still resulted in cell death. These results suggest that histatin 5-induced cell death inS. cerevisiaediffers from that inC. albicans. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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