| Autor: |
Farmaki, Evangelia, Papachristou, Fotis, Winn, Richard M., Karatzas, Nicolas, Sotiriou, John, Roilides, Emmanuel |
| Předmět: |
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| Zdroj: |
Pediatric Nephrology; Feb2005, Vol. 20 Issue 2, p180-183, 4p |
| Abstrakt: |
Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-ß1 (TGF-ß) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-ß was detected in the urine of 52% of 48 children aged 1-24 months with a first episode of UTI (94% due toEscherichia coli) and no obstructive nephropathy compared with 0 of 20 healthy young children (P<0.001).TGF-ß was detected in the urine only during the early stage (<1 day) after initiation of treatment. It was detected more frequently (P=0.06) and in significantly higher concentrations (P=0.046) in children with a normal99mTc-dimercaptosuccinic acid scan compared with those with abnormal scans performed 3-14 days after the diagnosis of UTI, suggesting a regulatory role in fibrogenesis and outcome of pyelonephritis in childhood. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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