| Autor: |
Kaplan, M. H., Alhasan, S., Rosenspire, A., Sundick, R. S. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; Aug1993, Vol. 38 Issue 2, p153-157, 5p |
| Abstrakt: |
We have characterized a monoclonal antibody (AT389), produced by immunization of mice with 4-day old avian Concanavalin A blasts, which recognizes a 38-40 kDa homodimer present on the surface of all chicken T cells. AT389 increased the spontaneous and IL-2-driven proliferation or 3-day-old T-cell blasts. This antibody, in synergy with IL-2, increased cellular proliferation and cell survival of T-cell blasts over time. Together, these data suggest that AT389 recognizes a surface protein on avian T cells which may be related to known stimulatory surface markers on mammalian T cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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