| Abstrakt: |
Abstract—The current review provides data on the association between neuroinflammation and reconsolidation of memory. The first part of the review gives the general characteristics of the phenomenon of reconsolidation and the use of the destabilization phase of memory for its subsequent modifications to erase a negative memory. We also describe the role of the immune system (microglia and astrocytes) in the formation of neuroinflammation and the participation of the proinflammatory agents in diseases associated with cognitive disorders (Alzheimer's and Parkinson's diseases). In the next section, we discuss the influence of neuroinflammation on behavioral manifestations of negative memory reconsolidation, molecular-cellular mechanisms, and signaling pathways involved in its impairment under the influence of proinflammatory cytokines. We also describe the modulatory influence of neuroinflammation on the reconsolidation of positive memory (associated with drug use) on models of self-administration of drugs and conditioned place preference with concomitant molecular-cellular mechanisms and structures involved that are associated with the reinforcing properties of drugs. [ABSTRACT FROM AUTHOR] |
Full text from SpringerLink