| Autor: |
Yasuda, Tatsuji, Kanegasawi, Shiro, Tsumita, Toru, Tadakuma, Takushi, Homma, J. Yuzura, Inage, Masaru, Kusumoto, Shoichi, Shiba, Tetsuo |
| Předmět: |
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| Zdroj: |
European Journal of Biochemistry; 5/17/82, Vol. 124 Issue 2, p405-407, 3p |
| Abstrakt: |
The adjuvant effect of synthetic analogues of lipid A was investigated in mice in vivo. Two of the five synthetic lipid A analogues showed adjuvant activity when they were incorporated into dipalmitoylglycerophosphocholine -- cholesterol --dipalmitoylglycerophosphate liposomes sensitized with trinitrophenylaminocaproylglycerophosphoethanolamine. The minimum structure for an adjuvant effect in the liposomal immunogen system was 1-mono-phosphate of 6-O-(2-deoxy-2-tetradecanoylamino-6-O-tetradeeanoyl-D-glucopyranosyl)-2-deoxy-2-tetradecanoylamino- 3,4-di-O-tetradecanoyl-D-glucopyranose. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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