| Autor: |
Prakash, M. Durga, Krsihna, B. Vamsi, Satyanarayana, B. V. V., Vignesh, N. Arun, Panigrahy, Asisa Kumar, Ahmadsaidulu, Shaik |
| Zdroj: |
SILICON (1876990X); Jul2022, Vol. 14 Issue 10, p5683-5690, 8p |
| Abstrakt: |
This study evolves an ultrasensitive label free electrical device, the silicon nanowire field effect transistor (SiNW FET) for cardiac troponin I (cTnI) in acute myocardial infarction (AMI). In this work, SiNW FET is designed, simulated using COMSOL semiconductor module to identify the presence of different concentrations of cTnI present in human blood. The surface of the SiNW is functionalized with the cTnI monoclonal antibody (mAb-cTnI) on attached to detect cTnI antigen. The response of the device is also studied using cTnI at different concentrations with the lowest limit of detection of 0.002 ng/mL. The presented SiNW FET in this study shows considerable response than the earlier developed devices and signify impressive capability for subsequent implementation in point-of-care (PoC) detection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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