| Autor: |
Faisal, Rizwan, Anwar, Attia, Khokhar, Aamna, Sattar, Afeefah, Jamil, Ayesha, Jamal, Arif |
| Předmět: |
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| Zdroj: |
Pakistan Armed Forces Medical Journal; Jun2022, Vol. 72 Issue 3, p822-825, 4p |
| Abstrakt: |
Objective: To determine the anti-inflammatory activity of crude extract of Aesculus Indica in the rat model. Study Design: Laboratory-based experimental study. Place and Duration of Study: Pharmacy Department, Bahauddin Zakria University, Multan Pakistan, from May to Oct 2018. Methodology: Twenty-four healthy male and female Wistar rats (200-220gm) were included in the study. Each rat was given a single injection of 0.1 ml of 1% Carrageenan mixed in normal saline in the sub-planter region of the right paw for oedema induction. The rats were randomly divided by lottery method into four groups; Group-1 served as positive control; Group-2 and 3 received a crude extract of Aesculus Indica 100 mg/kg and 300mg/kg, respectively; Group-4 was given Aspirin at the dose of 12 mg/kg. The measurement of paw volume was made by displacement technique using the plathysmometer before and at 1st, 2nd, 3rd and 4th hour after the Carrageenan injection. Results: The results confirmed the anti-inflammatory action of crude extract of Aesculus indica both at 100 mg/kg and 300 mg/kg. When Group-1 was compared with Groups 2, 3 and 4, it revealed a significant difference with a p-value of 0.002, 0.04 and 0.002, respectively. Similarly, after 3 hours of Carrageenan-induced oedema, the comparison of Group-2 with Group-3 showed a significant difference with a p-value of 0.03, while an insignificant difference was found between Groups-3 and 4. An insignificant difference of p-value of 0.07 was found when groups 2 and 4 were compared. Conclusion: Crude extract of the Aesculus Indica showed significant anti-inflammatory properties, which at high doses were almost comparable with that of Aspirin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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