| Autor: |
Zaitseva, M. B., Moshnikov, S. A., Kozhich, A. T., Frolova, H. A., Makarova, O. D., Pavlikov, S. P., Sidorovich, I. G., Brondz, B. B. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; Mar1992, Vol. 35 Issue 3, p267-273, 7p |
| Abstrakt: |
Seventy-five per cent of sera from HIV-I-infected individuals bind to the human 9-lymphoma cells bearing the major histocompatibility class II molecule in enzyme-linked immunosorbent assay (ELISA). The binding is caused by the antibodies against the class 11 molecule present in the serum samples which prevent the interaction of murine anti-HLA.DR monoclonal antibody with B lymphoma in FACS analysis. The three highly conserved amino acid sequences in α- and β- chains of the class 11 molecule and three homologous fragments in HIV-1 gp120 and gp41 were identified by computer search and synthesized. Using these peptides it was demonstrated that 28-48% of HIV-positive sera contain antibodies that cross-react with the peptide of HlV-1 origin and with the peptide from the class II molecule as well. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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