| Autor: |
Andersson, K., Hansson, U.-B., Alkner, U. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; Jun1992, Vol. 35 Issue 6, p703-710, 8p |
| Abstrakt: |
Two preparations of human IgG, one acolyte with β-propiolactone (acolyte IgG) and one treated at pH 4 with traces of pepsin (pH4-lgG). were used to study the effect of non-immune IgG on antigen antibody interactions in the antigen excess zone. Employing two immunological methods together with site-exclusion chromatography, we found that the formation of" human albumin rabbit anti-human albumin complexes was inhibited in the presence of human IgG, In addition, IgG seemed lo promote the aggregation of already formed complexes. Thus, nonimmune IgG may modulate immune complexation by direct molecular interactions. The effect was dependent on the site and composition of the immune complexes as well as on the conformation of the IgG molecules with respect to their shape, iso type, charge, and other surface properties. Some possible mechanisms for the reactions are discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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