Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues.

Autor: Djaló, Mariama, Silva, Maria J. S. A., Faustino, Hélio, Pinto, Sandra N., Mendonça, Ricardo, Gois, Pedro M. P.
Předmět:
Zdroj: Chemical Communications; 7/21/2022, Vol. 58 Issue 57, p7928-7931, 4p
Abstrakt: The site-selective chemical appendage of multiple functionalities on a native peptide backbone is a highly demanding and complex tool of modern chemical biology. Here, novel NHS-activated acrylates were designed to hold various payloads in a single bioconjugation handle that is able to site-selectively and orthogonally target the N-terminal cysteine of peptides. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index