| Abstrakt: |
Background: Numerous risk factors for the development of hernia have been identified, including abnormal collagen fiber organization and increased intra-abdominal pressure. Objectives: The purpose of this study is to investigate if one or both of these factors (arrangement of collagen fibers and increased intra-abdominal pressure) contribute to the formation of hernias. Materials and Methods: Adolescents and adults with anterior abdominal wall hernia were admitted to the hospital and underwent surgery after completing a standard preoperative evaluation protocol that included a detailed medical history, physical examination, and laboratory tests. Prior to anesthesia induction in the operation room, intra-abdominal pressure was measured using a Foley's catheter attached to a pressure transducer. According to their condition, the patients underwent routine surgery, either laparoscopic or open. Excision of the sac and submission to the histo-pathological examination for collagen analysis using two different stains, Masson's trichrome and Gomori's reticulin. Categorical variables were quantified using numbers and percentages (percent), whereas continuous variables were quantified using the mean, standard deviation, and median. The chi-square test was used to ascertain correlations between qualitative variables. P < 0.05 was considered statistically significant. Results: We considered a total of 200 patients, 50 of whom served as controls. Elevated intra-abdominal pressure has been identified as a risk factor for ventral wall hernia. Collagen fibers in patients with hernias were found to be disorganized at the microscopic level. Obesity and elevated intra-abdominal pressure were found to be statistically significant predictors of collagen disorder and the development of hernias. Hernias are more likely to occur as people age. Although chronic cough has been linked to metabolic disorders such as diabetes, hypertension, and kidney disease, we found no statistically significant link. Conclusions: Intra-abdominal pressure elevation, disordered collagen fiber arrangement, obesity and increasing age are risk factors associated with hernia development. [ABSTRACT FROM AUTHOR] |
